You can use "centre cancel" functions on some hi-fi/karaoke systems, and within some wave player programs, but it doesn't really work properly. It works on the presumption that all of the vocal is placed in the centre of the stereo-field, but usually, the way songs are mixed these days, there is reverb and various other effects that bounce across the stereo spectrum, meaning when you "centre cancel" you can still here some of the voice faintly in the background.
I remix and produce so i get a lot of stuff like that. It's a very hard song to remix, even using the instrumental is hard because it changes tempo slightly at different points.
